AVNIR^TM Technology

Functionalized vesicles accelerating vaccine and antiviral drug discoveries

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Recreating the biological complexity

The AVNIR^TM technology accurately mimics interactions between virus and host cells using functionalized artificial vesicles. The outer membrane of these artificial cells and artificial viruses is made of biological molecules originally found in their natural model (receptors, co-receptors, antigens, enzymes, and other proteins and lipids). Those biomolecules are biologically functional since they keep their original full-length, conformation, and post-translational modifications.

The AVNIR^TM technology relies on functionalizable artificial vesicles able to reproduce the native complexity and diversity of cell and virus surface composition using synthetic biology.

Custom vesicles

The AVNIR^TM technology enables customization of the artificial vesicle’s surface by displaying several types of biomolecules from different cell types and virus strains. Therefore, several viruses and host cells can be mimicked by creating chimeric biological nanoparticles.

Engineered brightness

The artificial cells and artificial viruses can be engineered to be bright, enabling their detection with common optical instruments. Different types of light signals can be used such as fluorescence and luminescence read out.

Advanced neutralization tests

Bioassays are essential tools for developing antiviral drugs and vaccines, playing a crucial role in decision-making throughout the discovery process and ultimately delivering new therapeutic solutions to patients.

The AVNIR^TM technology represents an innovative solution that overcomes limitations associated with cell culture and viruses in conventional cell-based assays, while maintaining biological realism. With this technology, IVANO Bioscience’s team is developing next-generation surrogate neutralization assay products known as AbVenger^TM kits.

AbVenger^TM kits

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Leading the way in cutting-edge neutralizing antibody detection with AbVenger^TM, the upcoming next generation neutralization kits

AbVenger^TM kits

FAQ

What kind of cells can be mimicked?

The AVNIR technology can mimic any cell types. Several surface markers can be exposed on the outer surface of our artificial cells.

What kind of virus can be mimicked?

The AVNIR technology is a powerful biotechnology engineering to simulate the surface of several enveloped and non-enveloped.