AVNIRTM Technology

Functionalized vesicles accelerating vaccine and antiviral drug discoveries

Artificial cells and artificial pathogens are interacting to simulate the natural process - Ivano Bioscience

Recreating the biological complexity

The AVNIRTM technology accurately mimics interactions between virus and host cells using functionalized artificial vesicles. The outer membrane of these artificial cells and artificial viruses is made of biological molecules originally found in their natural model (receptors, co-receptors, antigens, enzymes, and other proteins and lipids). Those biomolecules are biologically functional since they keep their original full-length, conformation, and post-translational modifications.

Artificial membrane made by biotechnology engineering for vaccine development

The AVNIRTM technology relies on functionalizable artificial vesicles able to reproduce the native complexity and diversity of cell and virus surface composition using synthetic biology.

AVNIR biotechnology: Artificial vesicles for natural interaction replication for vaccine development applications

Customizable receptors and antigens of artificial particles - Ivano Bioscience

Custom vesicles

The AVNIRTM technology enables customization of the artificial vesicle’s surface by displaying several types of biomolecules from different cell types and virus strains. Therefore, several viruses and host cells can be mimicked by creating chimeric biological nanoparticles.

The new generation technology used in IVANO Bioscience’s neutralization bioassay kit

Engineered brightness

The artificial cells and artificial viruses can be engineered to be bright, enabling their detection with common optical instruments. Different types of light signals can be used such as fluorescence and luminescence read out.

The AbVenger kit, a new generation technology for neutralization bioassay kit, useful in vaccine and immunotherapy development

Advanced neutralization tests

Bioassays are essential tools for developing antiviral drugs and vaccines, playing a crucial role in decision-making throughout the discovery process and ultimately delivering new therapeutic solutions to patients.

The AVNIRTM technology represents an innovative solution that overcomes limitations associated with cell culture and viruses in conventional cell-based assays, while maintaining biological realism. With this technology, IVANO Bioscience’s team is developing next-generation surrogate neutralization assay products known as AbVengerTM kits.

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Leading the way in cutting-edge neutralizing antibody detection with AbVengerTM, the upcoming next generation neutralization kits

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What kind of cells can be mimicked?

What kind of virus can be mimicked?

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Academie Entrepreneuriale ULaval - CDPQ - Ivano Bioscience Partner BIOQueebec - Ivano Bioscience Partner CenTech - Ivano Bioscience Partner NRC Canada - Ivano Bioscience Partner District 3 - Ivano Bioscience Partner Eggenius ULaval - Ivano Bioscience Partner Entrepreneuriat ULaval - Ivano Bioscience Partner Quebec - Ivano Bioscience Partner Défi OSEntreprendre Sceau lauréat régional - Ivano Bioscience Partner Proeto - Ivano Bioscience Partner