SARS-CoV-2 Pseudovirus, B.1.1.7 (Alpha) variant

Comprehensive Neutralization Assay Solutions for Advancing COVID-19 Research

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B.1.1.7 (Alpha) variant Advantages

This pseudovirus is pseudotyped with the Spike Glycoprotein of SARS-CoV-2 virus, B.1.1.7 (Alpha) variant (GISAID Accession Number: EPI_ISL_1164753). This pseudovirus carries a modified genome that expresses a luciferase reporter gene (GFP on request).

Up to 1,000 reactions per mL (96-well plate)

Get a signal-to-background ratio of ≥10³ with 1 µL per well

Infectious titer of at least 10⁵ RLU/µL

The transduction efficiency is evaluated using HEK293 ACE2⁺ cells.

Lot to lot functionally validated

Infectivity and neutralization are evaluated for each batch

Lead Time: 2 - 3 week

We provide you with freshly produced pseudoviruses

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Features

Enable specific detection

Expression of Spike glycoprotein, from B.1.1.7 Alpha variant, as the sole surface antigen

Enhanced safety

Our pseudoviruses use a 3rd-generation lentivirus core and must be handled in BSL-2 conditions

Characterization of thermal stability

Stable at least 6 month at -80 °C

Support high-throughput screening

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Applications

Pseudoviruses provide a safe and versatile platform for SARS-CoV-2 virus research and the development of therapeutic countermeasures. SARS-CoV-2 pseudoviruses have several important applications in research and development, including:

Vaccine Development

They are used to test the efficacy of new vaccines by evaluating their ability to induce neutralizing immune responses without the need for live pathogenic viruses.

Neutralizing Monoclonal Antibody Screening

Pseudoviruses enable rapid and safe screening of monoclonal antibodies targeting specific strains of the SARS-CoV-2 virus.

Antiviral Resistance Studies

They help study viral mutations and evaluate how these mutations affect sensitivity to antiviral treatments.

Fundamental Research on Viral Entry

Pseudoviruses are used to understand the mechanisms of viral entry into host cells, which is crucial for developing new therapies targeting these processes.

Treatment Efficacy Testing

They allow for the quick assessment of new antiviral agents’ effectiveness in controlled environments without the risks associated with highly pathogenic viruses.

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B.1.1.7 (Alpha) Variant's Background

The SARS-CoV-2 Alpha variant (lineage B.1.1.7) is a highly transmissible variant of concern first identified in the United Kingdom in late 2020 and rapidly spread across multiple countries (WHO). Alpha is characterized by several key mutations in the spike protein—including N501Y, P681H, and the deletion Δ69–70—which enhance binding affinity to the ACE2 receptor and facilitate viral entry into host cells (Public Health England, 2020–2021). Compared with earlier SARS-CoV-2 strains, the Alpha variant is associated with increased transmissibility and higher viral loads, contributing to its rapid dominance in many regions during early 2021 (Davies et al., 2021; Volz et al., 2021). Although vaccines remained largely effective, some studies suggested modest impacts on neutralization, underscoring the need for ongoing genomic surveillance and adaptive public health responses (CDC).

SARS-CoV-2 pseudovirus, B.1.1.7 (Alpha) in Publications

The emergence and global spread of the SARS-CoV-2 B.1.1.7 (Alpha) variant, characterized by increased transmissibility and partial immune escape, underscored the need for effective vaccines and antiviral strategies against evolving viral strains. By eliminating the need to handle infectious BSL-3 virus, pseudovirus neutralization assays offer a safe, rapid, scalable, and standardized platform for evaluating neutralizing monoclonal antibodies (mAbs) and antiviral compounds targeting the spike (S) protein of SARS-CoV-2 variants.

SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral Spike vaccines

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Documentation

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