SARS-CoV-2 Pseudovirus, BA.1 (Omicron) variant

Comprehensive Neutralization Assay Solutions for Advancing COVID-19 Research

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BA.1 (Omicron) variant Advantages

This pseudovirus is pseudotyped with the Spike Glycoprotein of SARS-CoV-2 virus, BA.1 (Omicron) variant (GISAID Accession Number: EPI_ISL_10866182). This pseudovirus carries a modified genome that expresses a luciferase reporter gene (GFP on request).

Up to 1,000 reactions per mL (96-well plate)

Get a signal-to-background ratio of ≥10³ with 1 µL per well

Infectious titer of at least 10⁴ RLU/µL

The transduction efficiency is evaluated using HEK293 ACE2⁺ cells.

Lot to lot functionally validated

Infectivity and neutralization are evaluated for each batch

Lead Time: 2 - 3 week

We provide you with freshly produced pseudoviruses

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Features

Enable specific detection

Expression of Spike glycoprotein, from BA.1 (Omicron) variant, as the sole surface antigen

Enhanced safety

Our pseudoviruses use a 3rd-generation lentivirus core and must be handled in BSL-2 conditions

Characterization of thermal stability

Stable at least 6 month at -80 °C

Support high-throughput screening

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Applications

Pseudoviruses provide a safe and versatile platform for SARS-CoV-2 virus research and the development of therapeutic countermeasures. SARS-CoV-2 pseudoviruses have several important applications in research and development, including:

Vaccine Development

They are used to test the efficacy of new vaccines by evaluating their ability to induce neutralizing immune responses without the need for live pathogenic viruses.

Neutralizing Monoclonal Antibody Screening

Pseudoviruses enable rapid and safe screening of monoclonal antibodies targeting specific strains of the SARS-CoV-2 virus.

Antiviral Resistance Studies

They help study viral mutations and evaluate how these mutations affect sensitivity to antiviral treatments.

Fundamental Research on Viral Entry

Pseudoviruses are used to understand the mechanisms of viral entry into host cells, which is crucial for developing new therapies targeting these processes.

Treatment Efficacy Testing

They allow for the quick assessment of new antiviral agents’ effectiveness in controlled environments without the risks associated with highly pathogenic viruses.

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BA.1 (Omicron) Variant's Background

The SARS-CoV-2 Omicron variant BA.1 is a highly transmissible variant of concern first identified in southern Africa in late 2021 and rapidly spread worldwide (WHO). BA.1 is characterized by an unusually high number of mutations in the spike protein—including N501Y, K417N, and E484A, as well as multiple deletions and insertions, which affect receptor binding and antigenicity (CDC). Several of these mutations are associated with increased binding affinity to the ACE2 receptor and enhanced transmissibility, while others contribute to immune evasion.

Compared with earlier SARS-CoV-2 variants, Omicron BA.1 is associated with markedly increased transmissibility and rapid spread, leading to its global dominance by early 2022 (WHO; CDC). In addition, BA.1 shows substantial resistance to neutralizing antibodies from prior infection or vaccination, resulting in reduced vaccine effectiveness against infection, although protection against severe disease remains largely preserved (Planas et al., 2022; Cele et al., 2022). These characteristics highlight the importance of continued genomic surveillance, vaccine updates, and booster strategies to mitigate the impact of emerging variants.

SARS-CoV-2 pseudovirus, BA.1 (Omicron) in Publications

The emergence and global spread of the SARS-CoV-2 BA.1 (Omicron) variant, characterized by increased transmissibility and partial immune escape, underscored the need for effective vaccines and antiviral strategies against evolving viral strains. By eliminating the need to handle infectious BSL-3 virus, pseudovirus neutralization assays offer a safe, rapid, scalable, and standardized platform for evaluating neutralizing monoclonal antibodies (mAbs) and antiviral compounds targeting the spike (S) protein of SARS-CoV-2 variants.

A Pseudovirus-Based Neutralization Assay for SARS-CoV-2 Variants: A Rapid, Cost-Effective, BSL-2–Based High-Throughput Assay Useful for Vaccine Immunogenicity Evaluation

 

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