SARS-CoV-2 Pseudovirus, LP.8.1 variant

Comprehensive Neutralization Assay Solutions for Advancing COVID-19 Research

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LP.8.1 variant Advantages

This pseudovirus is pseudotyped with the Spike Glycoprotein of SARS-CoV-2 virus, LP.8.1 variant (GISAID Accession Number: EPI_ISL_19467828). This pseudovirus carries a modified genome that expresses a luciferase reporter gene (GFP on request).

Up to 500 reactions per mL (96-well plate)

Get a signal-to-background ratio of ≥10³ with 2 µL per well

Infectious titer of at least 10⁴ RLU/µL

The transduction efficiency is evaluated using HEK293 ACE2⁺ cells.

Lot to lot functionally validated

Infectivity and neutralization are evaluated for each batch

Lead Time: 2 - 3 week

We provide you with freshly produced pseudoviruses

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Features

Enable specific detection

Expression of Spike glycoprotein, from LP.8.1 variant, as the sole surface antigen

Enhanced safety

Our pseudoviruses use a 3rd-generation lentivirus core and must be handled in BSL-2 conditions

Characterization of thermal stability

Stable at least 6 month at -80 °C

Support high-throughput screening

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Applications

Pseudoviruses provide a safe and versatile platform for SARS-CoV-2 virus research and the development of therapeutic countermeasures. SARS-CoV-2 pseudoviruses have several important applications in research and development, including:

Vaccine Development

They are used to test the efficacy of new vaccines by evaluating their ability to induce neutralizing immune responses without the need for live pathogenic viruses.

Neutralizing Monoclonal Antibody Screening

Pseudoviruses enable rapid and safe screening of monoclonal antibodies targeting specific strains of the SARS-CoV-2 virus.

Antiviral Resistance Studies

They help study viral mutations and evaluate how these mutations affect sensitivity to antiviral treatments.

Fundamental Research on Viral Entry

Pseudoviruses are used to understand the mechanisms of viral entry into host cells, which is crucial for developing new therapies targeting these processes.

Treatment Efficacy Testing

They allow for the quick assessment of new antiviral agents’ effectiveness in controlled environments without the risks associated with highly pathogenic viruses.

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LP.8.1 Variant's Background

The SARS-CoV-2 Omicron variant LP.8.1 (a descendant lineage within the JN.1 sublineage) is a recently emerging variant that has shown increasing circulation in multiple regions since late 2024 (WHO). LP.8.1 is characterized by additional mutations in the spike protein relative to its parent JN.1 lineage, including substitutions in the receptor-binding domain that may influence transmissibility and antibody recognition (CDC).

Compared with earlier Omicron sublineages, LP.8.1 appears to exhibit a growth advantage, contributing to its gradual increase in prevalence in certain geographic areas (WHO; CDC). Similar to other recent Omicron descendants, LP.8.1 is associated with immune escape properties that may reduce neutralization by antibodies from prior infection or vaccination, although current vaccines are still expected to provide protection against severe disease (WHO; CDC).

While there is no clear evidence of increased disease severity associated with LP.8.1, its evolutionary trajectory highlights ongoing viral adaptation and the importance of continued genomic surveillance and updated vaccination strategies to limit the impact of emerging SARS-CoV-2 variants.

SARS-CoV-2 pseudovirus, LP.8.1 in Publications

The emergence and global spread of the SARS-CoV-2, LP.8.1 variant, characterized by increased transmissibility and partial immune escape, underscored the need for effective vaccines and antiviral strategies against evolving viral strains. By eliminating the need to handle infectious BSL-3 virus, pseudovirus neutralization assays offer a safe, rapid, scalable, and standardized platform for evaluating neutralizing monoclonal antibodies (mAbs) and antiviral compounds targeting the spike (S) protein of SARS-CoV-2 variants.

Neutralization escape, infectivity, and membrane fusion of JN.1-derived SARS-CoV-2 SLip, FLiRT, and KP.2 variants

 

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